• SIRT4-Mediated Glutamine Metabolism Modulation in Liver Fibr

  2026-07-01

  This article reviews a recent study highlighting how targeting glutamine metabolism in hepatic stellate cells (HSCs) via SIRT4-mediated regulation alleviates liver fibrosis. The findings offer mechanistic insight into antifibrotic strategies by modulating cellular energy pathways, with practical implications for metabolic and autophagy research.

• Cy5 TSA Fluorescence System Kit: Elevating Signal Amplificat

  2026-06-30

  The Cy5 TSA Fluorescence System Kit brings unmatched sensitivity and specificity to spatial proteomics, IHC, and FISH workflows, enabling single-cell-type resolution and robust detection of low-abundance targets. Its HRP-catalyzed tyramide deposition and rapid fluorescent labeling dramatically enhance experimental throughput and clarity, as evidenced by recent advances in proximity proteomics.

• BmTyr-Based Biotin-Free Proximity Labeling in Primary T Cell

  2026-06-30

  The reference study introduces a copper-dependent BmTyr platform enabling bioorthogonal, biotin-free proximity labeling for subcellular proteome profiling in primary T cells. This innovation addresses longstanding limitations of biotin-based and antibody-dependent methods, offering new insights into nuclear protein networks and signaling dynamics with improved specificity and flexibility.

• Pazopanib Hydrochloride: Workflows & Troubleshooting in Canc

  2026-06-29

  Pazopanib Hydrochloride (GW786034) empowers researchers to dissect angiogenesis and tumor growth in advanced in vitro and in vivo models. This guide delivers actionable protocols, troubleshooting strategies, and data-driven insights for maximizing reproducibility in anti-angiogenic cancer research.

• Network Self-Assembly of Coil-Bottlebrush Diblocks in Ionic

  2026-06-29

  This study demonstrates that coil-bottlebrush diblock copolymers self-assemble into robust three-dimensional nanonetworks within alkylimidazolium-based ionic liquids, with phase behavior largely independent of the ionic liquid's alkyl chain length. These findings expand the design flexibility for nanostructured materials in ion-rich environments, advancing applications in membranes, nanofabrication, and energy devices.

• Superoxide Dismutase Activity Assay Kit: Advanced Insights &

  2026-06-28

  Explore advanced scientific applications of the Superoxide Dismutase Activity Assay Kit. This in-depth guide reveals how modern colorimetric SOD assays transform oxidative stress research with unique technical rigor.

• Silymarin in Experimental Oncology: Pathways, Protocols, and

  2026-06-27

  Explore silymarin, a milk thistle extract, as a pathway-specific probe in modern experimental oncology. This article uniquely dissects its mechanistic roles, protocol precision, and formulation nuances, bridging foundational chemistry with advanced cancer research.

• FAISL lncRNA Shields FAK from Calpain 2 to Drive TNBC Progre

  2026-06-26

  This study reveals that the long noncoding RNA FAISL stabilizes focal adhesion kinase (FAK) by directly blocking Calpain 2-mediated proteolysis, thereby enhancing cell adhesion and metastasis in triple negative breast cancer (TNBC). Targeting FAISL with siRNA-loaded nanoparticles suppresses tumor growth, highlighting a novel regulatory axis and potential therapeutic approach in aggressive breast cancer.

• Biotin-tyramide: Enabling Neurodevelopmental Mapping via TSA

  2026-06-26

  Explore how Biotin-tyramide empowers precise neurodevelopmental mapping through enzyme-mediated signal amplification. This article reveals unique insights into developmental neuroscience applications, offering a fresh perspective on biotin phenol chemistry and advanced imaging workflows.

• Flubendazole: Autophagy Modulation and Research Utility

  2026-06-25

  Flubendazole is a benzimidazole derivative and potent autophagy activator widely used in experimental biology. Its high purity, DMSO solubility, and defined molecular structure enable reproducible autophagy modulation research across cancer and neurodegeneration studies. This article details its mechanistic basis, evidentiary benchmarks, and integration strategies.

• Dual-Mode Tracking and Translation: EZ Cap™ Cy5 EGFP mRNA (5

  2026-06-25

  Explore the advanced capabilities of EZ Cap™ Cy5 EGFP mRNA (5-moUTP), a Cy5-labeled mRNA enabling simultaneous tracking and translation analysis in gene delivery research. This article uniquely bridges dual-mode fluorescence with recent breakthroughs in mRNA encapsulation, offering new insights beyond current literature.

• Pregnenolone Carbonitrile in Hepatic Detoxification & Fibros

  2026-06-24

  Pregnenolone Carbonitrile empowers researchers to dissect xenobiotic metabolism and antifibrotic pathways with unmatched selectivity for rodent PXR. This article delivers practical protocols, troubleshooting strategies, and novel insights from emerging studies, cementing PCN's status as a gold-standard tool for hepatic research.

• Hexetidine (NSC-17764): Applied Antimicrobial Workflows for

  2026-06-23

  Hexetidine (NSC-17764) stands out as a versatile antibacterial agent for oral infections, offering precise, reproducible results across biofilm inhibition assays and dental plaque models. This article delivers actionable workflows, troubleshooting strategies, and comparative insights to empower researchers in maximizing the compound’s impact using APExBIO’s trusted supply.

• Bioluminescent Probe Synthesis for Immunoproteasome Activity

  2026-06-23

  This study introduces a selective bioluminescent probe for the immunoproteasome (iCP), addressing the need for specific, versatile monitoring tools in disease-relevant contexts. The protocol demonstrates robust peptide synthesis and assay design, enabling precise iCP activity mapping in cells and tissue models.

• PSA-CD56/Siglec-7 Axis Drives Immune Evasion in ccRCC

  2026-06-22

  This study uncovers the polysialylated CD56 (PSA-CD56)/Siglec-7 axis as a novel glyco-immune checkpoint in clear cell renal cell carcinoma (ccRCC), mediating immune evasion by suppressing CD8+ T cell function and promoting apoptosis. Targeted disruption of this interaction restores anti-tumor immunity, providing new avenues for overcoming immunotherapy resistance.

7926 records 8/529 page Previous Next First page 上5页 678910 下5页 Last page