• Apelin is involved in various physiological

  2024-11-07

  

  Apelin is involved in various physiological functions, including 597 contraction (Ashley et al., 2005), vasodilatation (Jia et al., 2007), feeding control (Valle et al., 2008), and metabolic homeostasis (Higuchi et al., 2007, Dray et al., 2008, Attane et al., 2010). Its plasma level is elevated in

• The regulation of gene expression by glucocorticoids can

  2024-11-07

  

  The regulation of gene expression by glucocorticoids can be mediated either by the canonical mechanism that involves the interaction of the glucocorticoid receptor (GR), a transcription factor activated by the hormone, with glucocorticoid response element (Ye et al., 2007), or by the non-canonical m

• Use of antibiotics would be expected to

  2024-11-07

  

  Use of membrane transport would be expected to alter the maternal microbiome, thereby changing the infant's initial exposure is to the microbial environment, which could potentially lead to an abnormal succession of microbial colonization in the infant. Alterations in early microbial transfer and s

• Neural activity resulting from sensory experience is require

  2024-11-07

  

  Neural activity resulting from sensory experience is required for the refinement and maturation of neural circuits during cortical critical periods. This refinement is thought to be important for functional optimization of primary sensory cortices, enabling critical functions such as feature detecti

• As noted above yeasts particularly S cerevisiae

  2024-11-07

  

  As noted above, yeasts, particularly S. cerevisiae (Frey and Röhm 1978; Trumbly and Bradley 1983), produce APs, but these are intracellular enzymes located in the vacuolar compartment, with the exception of aminopeptidase II. About 40% of aminopeptidase II activity is detected as external enzyme, li

• Inflammatory factors released by activated cells during

  2024-11-07

  

  Inflammatory factors released by activated cells during AD are very important for the disease progression. Not only several inflammatory cytokines, such as IL-1β, IL-18, and IL-33, but also anti-inflammatory ones, as IL-10 and IL-13, are upregulated in the brain of AD patients (Morimoto et al., 2011

• Our previous work fails to show any maternal effect with

  2024-11-06

  

  Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef

• neurokinin receptor antagonist Neural progenitor cells NPCs

  2024-11-06

  

  Neural progenitor cells (NPCs) are self-renewing, multipotent cells that are capable of differentiating into neurons, astrocytes and oligodendrocytes. NPCs are activated in response to a variety of pathological states in neurodegenerative diseases such as Parkinson’s disease and multiple sclerosis,

• MicroRNA miRNA is an abundant group of small nucleotide nonc

  2024-11-06

  

  MicroRNA (miRNA) is an abundant group of small (22-nucleotide) noncoding RNA molecules that directly binds with 3′ untranslated region (UTR) of target messenger RNAs (mRNAs) to regulate gene expression, playing an important role in variety of biological processes including cell proliferation, apopto

• br Acknowledgements This work was supported by the National

  2024-11-06

  

  Acknowledgements This work was supported by the National Key Technology Research and Development Program (2012BAD19B01) and General Financial Grant from the China Postdoctoral Science Foundation (2015M581754). Introduction Cough is one of the most important defensive reflex brought into actio

• The indirect effect of corporate taxation as given by the

  2024-11-06

  

  The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard AVE 0991 effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) technology the cost effe

• Double immunofluorescence staining of Gas and Axl with neuro

  2024-11-06

  

  Double immunofluorescence staining of Gas6 and Axl with neuronal specific nuclear protein (NeuN), glial fibrillary acidic protein (GFAP), and ionized calcium-binding adaptor molecule 1 (Iba-1), demonstrated that Gas6 and Axl are expressed by neurons, astrocytes and microglia/macrophages (Fig. 2). In

• Since innate immune responses represent the first defense

  2024-11-06

  

  Since innate immune responses represent the first defense against incoming infectious microorganisms, they are particularly engaged during the early stages of viral infections. Many innate defense mechanisms rely on the engagement of pattern recognition receptors (PRRs) which are conserved, germ lin

• Aurora kinases are a conserved family of

  2024-11-06

  

  Aurora kinases are a conserved family of serine/threonine kinases that are important for the transition through mitosis and amplification and overexpression of Aurora kinases have been implicated in Ro 31-8220 receptor and transformation. Aurora B is located at the centromere and controls aspects of

• dna synthesis inhibitors antibiotics Here we report discover

  2024-11-06

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of dna synthesis inhibitors antibiotics bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity

13721 records 24/915 page Previous Next First page 上5页 2122232425 下5页 Last page