• br Guidance of B cell localization by EBI br EBI

  2021-04-20

  

  Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or progr

• br Methods br Results br Discussion Preclinical data

  2021-04-20

  

  Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the mefloquine hcl with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not signifi

• One possible explanation for differences in the binding abil

  2021-04-20

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• In conclusion DDR ECD was shown

  2021-04-20

  

  In conclusion, DDR1 ECD was shown to be sufficient for collagen mediated DDR1 oligomerization, and the oligomerized form binds to collagen with increased affinity. In full length receptors expressed on live cells, DDR1 oligomerization occurred on the cell surface in agreement with the role of DDR1

• Cystatins are potent inhibitors of cysteine proteases from t

  2021-04-20

  

  Cystatins are potent inhibitors of cysteine proteases from the C1A family. These inhibitors primarily reduce the activities of cathepsin L-like proteases, although high concentration of barley cystatin hampers the degradation of storage proteins caused by cathepsin F-like protein (HvPap-1) (Cambra e

• sennoside receptor Moreover recent structural studies of VEE

  2021-04-20

  

  Moreover, recent structural studies of VEEV nsP2pro in complex with E-64d revealed an important molecular interaction at the interface of two subdomains. In this structure, Asn475 which is in polar contact with carbonyl oxygen of Asp507 of the protease subdomain makes an H-bond with Arg662 of the MT

• br Rationale Recently we have shown that the nasal CysLT

  2021-04-20

  

  Rationale Recently we have shown that the nasal CysLT2 receptor localized exclusively in blood vessels and the expression level of the CysLT2 receptor in patients with nasal allergy was higher than that in patients with non-allergic rhinitis (Shirasaki et al. Allergol Int 2013). We hypothesized t

• On the other hand the properties

  2021-04-19

  

  On the other hand, the properties of collagen materials could be efficiently improved by proper chemical modification. The crosslinking agents for collagen generally involve aldehydes (e.g., glutaraldehyde (GA), isocyanates (e.g., hexamethylene diisocyanate (HMDI), photoreactive agents, polyepoxy co

• Finally we have determined for

  2021-04-19

  

  Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent monooxygenase receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al.,

• br Material and methods br Results br Discussion Both

  2021-04-19

  

  Material and methods Results Discussion Both progesterone and estradiol are major ovarian steroids crucial for the development and homeostasis of the female reproductive tract (Patel et al., 2015). In the cervix, estrogen softens the cervical stroma affecting the extracellular matrix (ECM)

• Ageing is associated with increased reactive

  2021-04-19

  

  Ageing is associated with increased reactive oxygen species (ROS) production, oxidative stress and oxidative damage [43,44]. Overproduction of ROS can impair endothelial function by suppressing NO synthesis and scavenging NO thereby decreasing its overall bioavailability. Moreover, sustained oxidati

• br EBV Infection Epstein Barr virus

  2021-04-19

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt's lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T

• Mulan protein level is regulated with conditions that stimul

  2021-04-19

  

  Mulan protein level is regulated with conditions that stimulate mitophagy such as treatment of folate analogue with CCCP [12]. We found that exogenously expressed GFP-GABARAP and RFP-Mulan could co-precipitate and co-localize in mammalian cells and the degree of co-localization increased when the c

• As the angular structure of compound cannot be differentiate

  2021-04-19

  

  As the angular structure of compound cannot be differentiated from the linear structure by H NMR spectroscopy, a NOESY NMR experiment was performed to unambiguously characterize the regioselectivity of the final compound. In the linear compound , a signature correlation between the proton of the t

• Structural homology modelling Intensive Phyre modelling

  2021-04-19

  

  Structural homology modelling. Intensive Phyre2 modelling [44] was performed using the primary amino L-Glutamine sequence of A1S_0222 as input to generate an atomistic 3D-homology model of A1S_0222. The fit to the SAXS data of the homology model as well as the fit to the data of the E. coli adenine

13830 records 622/922 page Previous Next First page 上5页 621622623624625 下5页 Last page