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On the opposite side sPLA X has also been
2021-03-24
On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer manufacturer and promotes their survival during nutrient stress. It acts through the products of its enzym
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TraM is one of two transfer proteins from pIP
2021-03-24
TraM is one of two transfer proteins from pIP501 T4SS that have structural similarity to the A. tumefaciens VirB8 protein (Fercher et al., 2016, Goessweiner-Mohr et al., 2013), a central member of the inner membrane complex (Bailey et al., 2006, Guglielmini et al., 2014, Trokter et al., 2014). VirB8
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Developmental relationships between CD bright
2021-03-24
Developmental relationships between CD56bright and CD56dim NK toxins remain unresolved; however, several studies indicate that the former is a precursor of the latter. An NK subset with intermediate features between CD56bright and CD56dim has been identified, corroborating this developmental traject
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Introduction Protein ubiquitination is a posttranslational m
2021-03-24
Introduction Protein ubiquitination is a posttranslational modification that plays a major role in almost all cellular processes in eukaryotes (Hochstrasser, 2009; Komander & Rape, 2012). It involves the covalent attachment of ubiquitin (Ub) via its C-terminal glycine carboxylate to a primary amine
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mu receptor antagonist br Synthesis and mechanism of fluores
2021-03-24
Synthesis and mechanism of fluorescent DNA-CuNMs Application of fluorescent DNA-CuNMs Summary and conclusions In summary, we introduce recent research progress in the synthesis and various applications of DNA-CuNMs. DNA-CuNMs with novel catalytic, electrical and optical properties can be ob
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Because conventional KO mice die
2021-03-24
Because conventional KO mice die within 24h of birth, it is difficult to analyze higher histamine receptors functions using them. Therefore, in this study, we generated brain-specific conditional DGKδ-KO mice and used these mice to perform behavioral and pharmacological tests. Results Discuss
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KU-0063794 br Materials and methods br Results br Discussion
2021-03-24
Materials and methods Results Discussion The present work demonstrates the functional role of DGAT2 in elevating the neutral lipid accumulation in engineered N. oceanica, which have aroused a great deal of interest in industrial scale biofuel production. Recently, there have been increasing
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br Enzymes involved in microbial steroid degradation are gen
2021-03-24
Enzymes involved in microbial steroid degradation are generally not expressed constitutively, but they are upregulated depending on which steroid substrates are present [17,81]. Thus, a cell-free extract prepared from testosterone-adapted C. testosteroni ATCC 11996 cells displayed a 1(2)-dehydroge
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br Introduction Lung cancer is the leading cause of cancer
2021-03-24
Introduction Lung cancer is the leading cause of cancer-related death worldwide, accounting for more than 1.5 million deaths in 2012. Non–small-cell lung cancers represent approximately 85% of lung neoplasms; among these, squamous cell carcinomas (SCC) account for approximately 30% of cases. The
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br Materials and methods br Acknowledgments This research wa
2021-03-24
Materials and methods Acknowledgments This research was supported by funding from University of California Irvine to H.U.B. Introduction Oral squamous cell carcinoma (OSCC) is the fourth major cause of mortality among men in Taiwan and its incidence rates continue to rise annually. OSCC is
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Water inorganic salts sugars lipids nucleic acids
2021-03-23
Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and
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Sodium ascorbate br Materials and methods br Results br Disc
2021-03-23
Materials and methods Results Discussion The effect of progestogen treatment showed some tendencies affecting the body length and weight, however these data were not verifiable statistically. This observation could be explained with the relatively short exposure period and/or the relatively
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What are the molecular signals that guide Tfh cells
2021-03-23
What are the molecular signals that guide Tfh cells as they navigate around the lymph node in the course of the immune response? It was recently reported that Tfh cells inside GCs have high expression of SIPR2, which acts to repel them from the S1P-rich lymph in the SCS and promote their retention i
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While oxysterols were most extensively studied for its poten
2021-03-23
While oxysterols were most extensively studied for its potent ability to mediate feedback regulation of cholesterol biosynthesis, some early investigations showed that the enzymes involved in its syntheses were highly upregulated in macrophages and dendritic cells—an indication of possible roles in
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br Acknowledgements The study of RING type E s
2021-03-23
Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01
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