• br Materials and methods br Results br

  2020-09-11

  

  Materials and methods Results Discussion DUSP1 is a member of the subfamily of the Dusl specific phosphatases (DUSPs). High levels of DUSP1 observed in lung, liver and placenta, and low levels have been found in the Kisspeptin 234 and kidney. DUSP1 has been shown to be elevated in various

• br Conclusions br Declaration of interest

  2020-09-11

  

  Conclusions Declaration of interest Acknowledgment This work was supported by an AIRC (Associazione Italiana Ricerca Cancro-Milan) Grant KFR062-2 to A.G.L, by Ricerca Funds by Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Grant No. 180/01) and by the ERA-NET “ERare” (Grant GO

• br Acknowledgment We thank Professor

  2020-09-11

  

  Acknowledgment We thank Professor Yuh-Chang Sun for providing helpful advice and the Ministry of Science and Technology of the Republic of China for financial support (grants MOST ). Introduction Past century has witnessed a tremendous increase in life expectancy of the human population, achi

• Exon encodes a section of the extracellular ligand binding d

  2020-09-10

  

  Exon 3 encodes a section of the extracellular ligand-binding domain and two variants in the 5′ region were first identified in Drosophila melanogaster (Semenov and Pak, 1999). These variants were initially termed modules 1 and 2 and correspond to exons 3a and 3b, respectively. To date, exon 3 altern

• br Introduction Rheumatoid arthritis RA is

  2020-09-10

  

  Introduction Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that can be divided in at least two subsets based on the presence of antibodies to citrullinated proteins (ACPAs) [1]. Importantly, such ACPA target proteins [[2], [3], [4], [5]] also represent candidate autoantige

• histamine receptor antagonist GPR also known as EBI

  2020-09-10

  

  GPR183 (also known as EBI2) is a Gαi-coupled seven-transmembrane chemotactic receptor. It is highly expressed on follicular B cells, CD4+ dendritic cells (DCs), and CD4+ T cells but is downregulated on germinal center (GC) histamine receptor antagonist in secondary lymphoid organs and controls cell

• Several of the keloid like lesions seen in these

  2020-09-10

  

  Several of the keloid-like lesions seen in these individuals were pigmented. It is of potential relevance that genetic variants in DDR1 [MIM: 600408] have been associated with vitiligo, and DDR1 activation is involved when gap junctions are attached to collagen-IV fibers. Because DDR1 and DDR2 are

• br Genotype phenotype correlations Genotype phenotype correl

  2020-09-10

  

  Genotype-phenotype correlations Genotype-phenotype correlations are limited. Compared with individuals with truncating variants, those with pathogenic missense variants in the adenosine triphosphate binding site had a milder disorder, some with ability to walk unaided, better hand use, and less r

• Palliative surgeries for refractory epilepsy include vagus

  2020-09-10

  

  Palliative surgeries for refractory epilepsy include vagus nerve stimulation and corpus callosotomy. Among 220 individuals with CDD with parent-entered data, 17% had a vagus nerve stimulation implanted and 69% of parents reported reduced seizure frequency. These data are consistent with a case repor

• Based on the ability of CRF to modulate

  2020-09-10

  

  Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur

• The mechanism by which these HIV PIs impair skeletal

  2020-09-10

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty d-glucose receptor translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular mem

• dofetilide One strategy which is different from the above is

  2020-09-10

  

  One strategy which is different from the above is to isolate a similar enzyme to the one under study which will not be recognized by the antibody of the original protein. This approach will lead to prolonging an enzyme’s activity. For example, a novel variant of Carboxypeptidase G2 (CPG2), which ha

• All tested antibodies exhibited positive immunoreactivity in

  2020-09-10

  

  All tested xmu exhibited positive immunoreactivity in NSCLC tumors, with N’-epitope being the less expressed (both as overall positivity and number of positive cases, or intensity combined with number of positive cells, as provided by H-Score. This result is in accordance with previous studies [18],

• In rodent models the loss of

  2020-09-10

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an 2768 receptor receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthase

• It remains unclear how LINE RNA

  2020-09-10

  

  It remains unclear how LINE1 RNA-Nucleolin-Kap1 are targeted to the Dux cluster. LINE1-Nucleolin-Kap1 may have other interacting partners with DNA binding specificity. For example, YY1 has been implicated in targeting a repressive complex containing Nucleolin to the human DUX4 cluster (Gabellini et 

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